PittsburghV1, Main, Exploration, bibRecord, 000760

Zebrafish models for translational neuroscience research: from tank to bedside

Identifieur interne : 000760 ( Main/Exploration ); précédent : 000759; suivant : 000761

Zebrafish models for translational neuroscience research: from tank to bedside

Auteurs : Adam Michael Stewart [États-Unis] ; Oliver Braubach [Corée du Sud] ; Jan Spitsbergen [États-Unis] ; Robert Gerlai [Canada] ; Allan V. Kalueff [États-Unis]

Source :

Trends in neurosciences [ 0166-2236 ] ; 2014.

RBID : PMC:4039217

Descripteurs français

KwdFr :
- Animaux, Danio zébré, Encéphalopathies (), Humains, Modèles animaux de maladie humaine, Neurosciences, Recherche médicale translationnelle ().
MESH :
- Animaux, Danio zébré, Encéphalopathies, Humains, Modèles animaux de maladie humaine, Neurosciences, Recherche médicale translationnelle.

English descriptors

KwdEn :
- Animals, Brain Diseases (therapy), Disease Models, Animal, Humans, Neurosciences, Translational Medical Research (methods), Zebrafish.
MESH :
- methods : Translational Medical Research.
- therapy : Brain Diseases.
- Animals, Disease Models, Animal, Humans, Neurosciences, Zebrafish.

Abstract

The zebrafish (Danio rerio) is emerging as a new important species for studying mechanisms of brain function and dysfunction. Focusing on selected central nervous system (CNS) disorders (brain cancer, epilepsy, and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience. We further evaluate the contribution of zebrafish to neuroimaging, circuit level, and drug discovery research. Outlining the role of zebrafish in modeling a wide range of human brain disorders, we also summarize recent applications and existing challenges in this field. Finally, we emphasize the potential of zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening, which is critical for CNS drug discovery and identifying novel candidate genes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039217

DOI: 10.1016/j.tins.2014.02.011
PubMed: 24726051
PubMed Central: 4039217

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">The zebrafish (<italic>Danio rerio</italic>
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Zebrafish models for translational neuroscience research: from tank to bedside

Zebrafish models for translational neuroscience research: from tank to bedside

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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